نتایج جستجو برای: cetp vaccine

تعداد نتایج: 110204  

Objective(s): In this study, for the first time, MF59 adjuvant was used to develop a cholesteryl ester transfer protein (CETP) vaccine. The efficacy of the vaccine was compared with the efficacy of CETP vaccine formulated with Alum/CpG, the formulation that its immunogenicity has been already demonstrated in rabbit and mice. Materials and Methods: Tetanus toxoid- CETP peptide (TT-CETP) was mixe...

Journal: :iranian journal of basic medical sciences 0
tamara aghebati nanotechnology research center, mashhad university of medical sciences, mashhad, iran amir hooshang mohammadpour pharmaceutical research center, mashhad university of medical sciences, mashhad, iran mohammad afshar department of anatomy, faculty of medicine, birjand university of medical sciences, birjand, iran medical toxicology research centre, mashhad university of medical sciences, mashhad, iran mahmoud reza jaafari biotechnology research center, mashhad university of medical sciences, mashhad, iran khalil abnous pharmaceutical research center, mashhad university of medical sciences, mashhad, iran

objective(s): in this study, for the first time, mf59 adjuvant was used to develop a cholesteryl ester transfer protein (cetp) vaccine. the efficacy of the vaccine was compared with the efficacy of cetp vaccine formulated with alum/cpg, the formulation that its immunogenicity has been already demonstrated in rabbit and mice. materials and methods: tetanus toxoid- cetp peptide (tt-cetp) was mixe...

2014
Yi-Wei Liaw Chi-Yu Lin Yu-Sheng Lai Tzu-Chung Yang Chau-Jong Wang Jacqueline Whang-Peng Leroy F. Liu Chia-Po Lin Shin Nieh Shao-Chun Lu Jaulang Hwang

Low HDL-C levels are associated with atherosclerosis and non-alcoholic steatohepatitis, and increased levels may reduce the risk of these diseases. Inhibition of cholesteryl ester transfer protein (CETP) activity is considered a promising strategy for increasing HDL-C levels. Since CETP is a self-antigen with low immunogenicity, we developed a novel CETP vaccine (Fc-CETP6) to overcome the low i...

2016
Tamara Aghebati Amir Hooshang Mohammadpour Mohammad Afshar Mahmoud Reza Jaafari Khalil Abnous Saeed Nazemi Sobhan Issazadeh Saeed Hashemzadeh Mohammad Zare Ali Badiee

OBJECTIVES In this study, for the first time, MF59 adjuvant was used to develop a cholesteryl ester transfer protein (CETP) vaccine. The efficacy of the vaccine was compared with the efficacy of CETP vaccine formulated with Alum/CpG, the formulation that its immunogenicity has been already demonstrated in rabbit and mice. MATERIALS AND METHODS Tetanus toxoid- CETP peptide (TT-CETP) was mixed ...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2000
C W Rittershaus D P Miller L J Thomas M D Picard C M Honan C D Emmett C L Pettey H Adari R A Hammond D T Beattie A D Callow H C Marsh U S Ryan

Using a vaccine approach, we immunized New Zealand White rabbits with a peptide containing a region of cholesteryl ester transfer protein (CETP) known to be required for neutral lipid transfer function. These rabbits had significantly reduced plasma CETP activity and an altered lipoprotein profile. In a cholesterol-fed rabbit model of atherosclerosis, the fraction of plasma cholesterol in HDL w...

Objective: Cholesteryl Ester Transfer Protein (CETP) mediates the transfer of cholesteryl ester from HDL-C to LDL-C and VLDL-C. The aim of the present trial was to evaluate the effect of curcumin and its modified formulation on serum CETP concentrations in patients with metabolic syndrome. Materials and Methods: Participants were randomly allocated to one of three groups of 40 subjects receivin...

2007
Patrick C.N. Rensen Christian Ehnholm Matti Jauhiainen Miranda Van Eck Dan Ye Reeni B. Hildebrand J. Kar Kruijt Willeke de Haan Menno Hoekstra Theo J.C. Van Berkel

Abundant amounts of cholesteryl ester transfer protein (CETP) are found in macrophage-derived foam cells in the arterial wall, but its function in atherogenesis is unknown. To investigate the role of macrophage CETP in atherosclerosis, LDL receptor knockout mice were transplanted with bone marrow from CETP transgenic mice, which express the human CETP transgene under control of its natural prom...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2002
Cheng-ai Wu Maki Tsujita Kuniko Okumura-Noji Shinichi Usui Hajime Kakuuchi Mitsuyo Okazaki Shinji Yokoyama

OBJECTIVE Regulation of plasma cholesteryl ester transfer protein (CETP) concentration was studied in lecithin-cholesterol acyltransferase (LCAT)-knockout mice. METHODS AND RESULTS LCAT-knockout mice were cross-bred with CETP transgenic mice. The offspring (n=63) were classified for LCAT genotype and plasma CETP levels (no CETP, low CETP, and high CETP). High density lipoprotein (HDL) decreas...

برخورداری, عسگر, حسن زاده, تقی, فتاحی, امیر, لطیفی, زینب, سعیدی جم, مسعود ,

Introduction & Objective: It has been shown that there is a correlation between cholesterol con-centration and coronary heart disease (CHD). Cholesteryl ester transfer protein (CETP) plays a central role in lipoproteins metabolism and it has been suggested that various polymorphisms in CETP gene can affect the enzyme activity and blood lipid parameters. There was not enough information about ...

2017
Ziyun Wang Manabu Niimi Qianzhi Ding Zhenming Liu Ling Wang Jifeng Zhang Jun Xu Jianglin Fan

Cholesteryl ester transfer protein (CETP) is a plasma protein that mediates bidirectional transfers of cholesteryl esters and triglycerides between low-density lipoproteins and high-density lipoproteins (HDL). Because low levels of plasma CETP are associated with increased plasma HDL-cholesterol, therapeutic inhibition of CETP activity is considered an attractive strategy for elevating plasma H...

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